There are nearly 300 mescal agave species in the world, native to the Southwest United States and Mexico. The agave plant has been used by Native peoples for numerous utilitarian items. Mescal is served as a valuable food source still being harvested and prepared to this day by many Indigenous groups. For millennia people have pit roasted the heart of the plant, yielding a nutritious food staple rich in calcium and zinc. This talk includes the life history of mescal, and the multitude of Tribal uses of this intriguing plant and their long relationship with this plant, from centuries ago to the modern era.